Cognitive decline in amyotrophic lateral sclerosis: Neuropathological substrate and genetic determinants.

ABSTRACT: Cognitive impairment and behavioral changes in amyotrophic lateral sclerosis (ALS) are now recognized as part of the disease. Whether it is solely related to the extent of TDP-43 pathology is currently unclear. We aim to evaluate the influence of age, genetics, neuropathological features, and concomitant pathologies on cognitive impairment in ALS patients. We analyzed a postmortem series of 104 ALS patients and retrospectively reviewed clinical and neuropathological data. We assessed the burden and extent of concomitant pathologies, the role of APOE ε4 and mutations, and correlated these findings with cognitive status. We performed a logistic regression model to identify which pathologies are related to cognitive impairment. Cognitive decline was recorded in 38.5% of the subjects. Neuropat

SUBMITTER: Borrego-Ecija S 

PROVIDER: S-EPMC8412113 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature