3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution.

ABSTRACT: Ribonucleic acid (RNA) nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment. However, the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery. Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional (3D) RNA nanocage. By placing an RNA three-way junction (3WJ) in the cavity of the nanocage, the conjugated hydrophobic molecules were specifically positioned within the nanocage, preventing their exposure to the biological environment. The assembly of the nanocages was characterized by native polyacryla

SUBMITTER: Xu C 

PROVIDER: S-EPMC8412138 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature