Identification of Immune-Related Genes in Sepsis due to Community-Acquired Pneumonia.

ABSTRACT:

Background

Immunosuppression has a key function in sepsis pathogenesis, so it is of great significance to find immune-related markers for the treatment of sepsis.

Methods

Datasets of community-acquired pneumonia (CAP) with sepsis from the ArrayExpress database were extracted. Differentially expressed genes (DEGs) between the CAP group and normal group by Limma package were performed. After calculation of immune score through the ESTIMATE algorithm, the DEGs were selected between the high immune score group and the low immune score group. Enrichment analysis of the intersected DEGs was conducted. Further, the protein-protein interaction (PPI) of the intersected DEGs was drawn by Metascape tools. Related publications of the key DEGs were searched in NCBI PubMed through Biopyth

SUBMITTER: Li Y 

PROVIDER: S-EPMC8413041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature