Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab.

ABSTRACT:

Introduction

Mucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma. Little is known regarding the efficacy of systemic therapy on its metastatic form because of its rarity.

Case presentation

We present the case of a patient with metastatic mucinous tubular and spindle cell carcinoma who achieved durable complete remission of multiple osseous metastases after undergoing cytoreductive nephrectomy followed by combination immunotherapy (ipilimumab plus nivolumab). Immunohistochemical analyses of the primary tumor revealed the presence of the tumor-infiltrating immune cells, including activated CD8⁺ T cells and PD-L1 expression, suggesting an immunologically hot tumor.

Conclusion

Combination immunotherapy was a viable treatment op

SUBMITTER: Fuchizawa H 

PROVIDER: S-EPMC8413205 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature