Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy.

ABSTRACT: Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H₂O₂) production and catalase for H₂O₂ degradation, which serves as an intracellular H₂O₂ regulator to degrade toxic peroxides to water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe₃O₄ nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Based on the O₂ redistribution and H₂O₂ activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical (·OH) and singlet oxygen (¹O₂

SUBMITTER: Qin X 

PROVIDER: S-EPMC8413279 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature