Screening and predicting progression from high-risk mild cognitive impairment to Alzheimer's disease.

ABSTRACT: Individuals with mild cognitive impairment (MCI) are clinically heterogeneous, with different risks of progression to Alzheimer's disease. Regular follow-up and examination may be time-consuming and costly, especially for MRI and PET. Therefore, it is necessary to identify a more precise MRI population. In this study, a two-stage screening frame was proposed for evaluating the predictive utility of additional MRI measurements among high-risk MCI subjects. In the first stage, the K-means cluster was performed for trajectory-template based on two clinical assessments. In the second stage, high-risk individuals were filtered out and imputed into prognosis models with varying strategies. As a result, the ADAS-13 was more sensitive for filtering out high-risk individuals among patients with MCI

SUBMITTER: Ge XY 

PROVIDER: S-EPMC8413294 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature