Ontology highlight
ABSTRACT:
SUBMITTER: Schachter NF
PROVIDER: S-EPMC8413298 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Schachter Nathan F NF Adams Jessica R JR Skowron Patryk P Kozma Katelyn J KJ Lee Christian A CA Raghuram Nandini N Yang Joanna J Loch Amanda J AJ Wang Wei W Kucharczuk Aaron A Wright Katherine L KL Quintana Rita M RM An Yeji Y Dotzko Daniel D Gorman Jennifer L JL Wojtal Daria D Shah Juhi S JS Leon-Gomez Paul P Pellecchia Giovanna G Dupuy Adam J AJ Perou Charles M CM Ben-Porath Ittai I Karni Rotem R Zacksenhaus Eldad E Woodgett Jim R JR Done Susan J SJ Garzia Livia L Sorana Morrissy A A Reimand Jüri J Taylor Michael D MD Egan Sean E SE
Nature communications 20210902 1
The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others driver non-specific, and still others associated with tumor histology. Processes affected by driver-specific and histology-specific mutations include well-known cancer pathways. Driver non-specific gCIS target the Mediator complex, Ca<sup ...[more]