The shared genetic architecture between epidemiological and behavioral traits with lung cancer.

ABSTRACT: The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (r_g) and SNP heritability (h²) between 347 traits and lung cancer risk using genome-wide association study summary statistics from the UKBB and OncoArray consortium. Further, we conducted analysis after removing genomic regions previously associated with smoking behaviors to mitigate potential confounding effects. We found significant negative genetic correlations between lung cancer risk and dietary behaviors, fitness metrics, educational attainment, and other psychosocial traits. Alcohol taken with meals (r_g

SUBMITTER: Pettit RW 

PROVIDER: S-EPMC8413319 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature