Effectiveness of corticosteroids to treat severe COVID-19: A systematic review and meta-analysis of prospective studies.

ABSTRACT:

Objectives

To assess the effects of corticosteroid therapy for patients with severe coronavirus disease 2019 (COVID-19).

Methods

We comprehensively searched articles published in the Cochrane Library, PubMed, Embase, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases from January 1, 2019, to March 20, 2021.

Results

A total of 6771 patients from eight prospective studies were included in our meta-analysis. The results showed that corticosteroid therapy was associated with lower mortality in severe COVID-19 (OR = 0.70, 95% CI = 0.54-0.92, P = 0.009; I² = 54.5%). Since the proportion of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial included in the meta-analysis was as high as 71.88%, we rem

SUBMITTER: Li H 

PROVIDER: S-EPMC8413363 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature