Telomere shortening in late-life depression: A potential marker of depression severity.

ABSTRACT:

Objectives

Telomeres are structures at the extremity of chromosomes that prevents genomic instability, and its shortening seems to be a hallmark of cellular aging. Past studies have shown contradictory results of telomere length (TL) in major depression, and are a few studies in late-life depression (LLD). This explores the association between TL as a molecular marker of aging and diagnosis of LLD, the severity of depressive symptoms, and cognitive performance in older adults.

Methods/design

We included 78 older adults (45 with LLD and 33 nondepressed controls, according to DSM-V criteria), aged 60-90 years. TL was measured in leukocytes by a quantitative polymerase chain reaction, determining the relative ratio (T/S) between the telomere region copy number (T) and a single

SUBMITTER: Mendes-Silva AP 

PROVIDER: S-EPMC8413729 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature