Alterations of the intrinsic amygdala-hippocampal network in juvenile myoclonic epilepsy.

ABSTRACT:

Introduction

Several lines of evidence suggest that the amygdala-hippocampus is involved in the epileptogenic network of juvenile myoclonic epilepsy (JME). The aim of this study was to investigate the alterations in the individual nuclei of the amygdala and hippocampal subfields, and the intrinsic amygdala-hippocampal network of patients with JME compared to healthy controls.

Methods

This retrospective study conducted at a single tertiary hospital involved 35 patients with newly diagnosed JME, and 34 healthy subjects. We calculated the individual structural volumes of 18 nuclei in the amygdala, and 38 hippocampal subfields using three-dimensional volumetric T1-weighted imaging and FreeSurfer program. We also performed an analysis of the intrinsic amygdala-hippocampal global

SUBMITTER: Lee DA 

PROVIDER: S-EPMC8413739 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature