External validity of randomized clinical trial studying preventing depressive symptoms following acute coronary syndrome.

ABSTRACT:

Objective

The objective of the current study was to quantitatively explore aspects of external validity, both researcher's choices (eligibility) and patient's choices (consent), of a recently conducted clinical trial.

Methods

A cohesive comparison between the MEDACIS trial (NCT02451293) database and a national quality and research database was conducted. Comparisons between both participants and nonconsenting patients (patient consent) and participants and noneligible patients (researcher selection) were performed. Comparisons of outcomes were depressive and anxiety symptoms, demographics, and somatic or psychiatric comorbidity.

Results

Noneligible patients had significantly higher levels of depressive symptoms and anxiety and were older and more likely to suffer from

SUBMITTER: Madsen MT 

PROVIDER: S-EPMC8413812 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature