Automatic classification of autism spectrum disorder in children using cortical thickness and support vector machine.

ABSTRACT:

Objective

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a heterogeneous phenotype. The role of biomarkers in ASD diagnosis has been highlighted; cortical thickness has proved to be involved in the etiopathogenesis of ASD core symptoms. We apply support vector machine, a supervised machine learning method, in order to identify specific cortical thickness alterations in ASD subjects.

Methods

A sample of 76 subjects (9.5 ± 3.4 years old) has been selected, 40 diagnosed with ASD and 36 typically developed subjects. All children underwent a magnetic resonance imaging (MRI) examination; T1-MPRAGE sequences were analyzed to extract features for the characterization and parcellation of regions of interests (ROI); average cortical thickness (CT) has been measu

SUBMITTER: Squarcina L 

PROVIDER: S-EPMC8413814 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature