Cortical connectivity in the face of congenital structural changes-A case of homozygous LAMC3 mutation.

ABSTRACT: The homozygous LAMC3 gene mutation is associated with severe bilateral smoothening and thickening of the lateral occipital cortex . Despite this and further significant changes in gray matter structure, a patient harboring this mutation exhibited a range of remarkably intact perceptual abilities . One possible explanation of this perceptual sparing could be that the white matter structural integrity and functional connectivity in relevant pathways remained intact. To test this idea, we used diffusion tensor and functional magnetic resonance imaging to investigate functional connectivity in resting-state networks in major structural pathways involved in object perception and visual attention and corresponding microstructural integrity in a patient with homozygous LAMC3 mutation and sex, age

SUBMITTER: Demirayak P 

PROVIDER: S-EPMC8413815 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature