Computational Design of a Multi-epitope Vaccine Against Clostridium chauvoei: An Immunoinformatics Approach.

ABSTRACT: Blackleg is an infectious disease of animals that is commonly caused by Clostridium chauvoei and characterized by localized muscle necrosis. In this study, proteome-mining and immunoinformatics approaches were applied to identify novel antigenic proteins and to construct a multi-epitope vaccine against C. chauvoei. All proteins of C. chauvoei strains were retrieved from the NCBI Microbial Genome Database containing both genomic and proteomic data of prokaryotes. The proteins were analyzed to exclude non-redundant sequences and to determine antigenic, virulent, and non-allergenic vaccine candidates through several online tools, resulting in seven protein candidates. Cytotoxic T and B cell epitopes of these proteins were evaluated through the tools present

SUBMITTER: Yılmaz Colak C 

PROVIDER: S-EPMC8414032 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature