HPLC-free and cassette-based nucleophilic production of [¹⁸F]FDOPA for clinical use.

ABSTRACT: Radiotracer 3,4-dihydroxy-6-[¹⁸F]fluoro-L-phenylalanine (L-6-[¹⁸F]fluorodopa or [¹⁸F]FDOPA) is widely used for PET imaging of dopamine metabolism in several diseases including Parkinson's Disease, brain tumor, neuroendocrine tumors, and focal hyperinsulinism of infancy. In 2019, [¹⁸F]FDOPA was approved by US FDA for detection of dopaminergic nerve terminals in the striatum of adult patients with suspected Parkinsonian Syndromes. A convenient and reliable method is desired for fully automated production of [¹⁸F]FDOPA under cGMP compliance to meet the increasing clinical need. In this study, we reported a cassette-based automated production of [¹⁸F]FDOPA using a GE Fastlab 2 module and the quality control (QC) under fully cGMP

SUBMITTER: Jiang H 

PROVIDER: S-EPMC8414396 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature