Associations Between <i>CYP17A1</i> and <i>SERPINA6/A1</i> Polymorphisms, and Cardiometabolic Risk Factors in Black South Africans.

ABSTRACT: Research in European and Asian populations has reported associations between single nucleotide polymorphisms (SNPs) in CYP17A1 and SERPINA6/A1 and circulating glucocorticoid concentrations, and some key cardiometabolic risk factors. This study aimed to investigate these associations in black South African adults, who are disproportionally affected by the metabolic syndrome and its related cardiometabolic risk factors. The dataset included black South African adults (n = 4,431; 56.7% women) from the AWI-Gen study, genotyped on the H3A genotyping array and imputed using the African reference panel at the Sanger imputation service. From the imputed data, 31 CYP17A1 SNPs and 550 SERPINA6/A1 SNPs were extracted. The metabolic syndrome and its components were d

SUBMITTER: Dlamini SN 

PROVIDER: S-EPMC8414563 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature