Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer.

ABSTRACT:

Background

Bladder cancer (BC) is the most common tumor of the urinary system. Non-muscle-invasive bladder cancer (NMIBC) has a high recurrence rate after surgery, and patients with muscle-invasive bladder cancer (MIBC) have poor quality of life after radical surgery. Understanding the molecular mechanism of bladder cancer is helpful for providing a more appropriate treatment approach. Annexins are calcium-binding proteins and play an important role in different tumor cells. However, the role of the annexin family in bladder cancer has not been studied in detail.

Methods

ONCOMINE, UALCAN, TIMER2.0, Kaplan-Meier Plotter, cBioPortal, and WebGestalt were utilized in this study.

Results

ANXA2, ANXA3, ANXA4, ANXA8, and ANXA9 were significantly increased in bladder tumor ti

SUBMITTER: Wu W 

PROVIDER: S-EPMC8414640 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature