Genetic Diversity of MHC B-F/B-L Region in 21 Chicken Populations.

ABSTRACT: The chicken major histocompatibility complex (MHC) on chromosome 16 is the most polymorphic region across the whole genome, and also an ideal model for genetic diversity investigation. The MHC B-F/B-L region is 92 kb in length with high GC content consisting of 18 genes and one pseudogene (Blec4), which plays important roles in immune response. To evaluate polymorphism of the Chinese indigenous chickens as well as to analyze the effect of selection to genetic diversity, we used WaferGen platform to identify sequence variants of the B-F/B-L region in 21 chicken populations, including the Red Jungle Fowl (RJF), Cornish (CS), White Leghorns (WLs), 16 Chinese domestic breeds, and two well-known inbred lines 6₃ and 7₂. A total of 3,319 single nucleotide polymorphism (SNPs)

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC8414643 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature