Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion.

ABSTRACT:

Background

Metal oxide nanoparticles (NPs) are increasingly used in many industrial and biomedical applications, hence their impact on occupational and public health has become a concern. In recent years, interest on the effect that exposure to NPs may exert on human reproduction has grown, however data are still scant. In the present work, we investigated whether different metal oxide NPs interfere with mouse cumulus cell-oocyte complex (COC) expansion.

Methods

Mouse COCs from pre-ovulatory follicles were cultured in vitro in the presence of various concentrations of two types of TiO₂ NPs (JRC NM-103 and NM-104) and four types of ZnO NPs (JRC NM-110, NM-111, and in-house prepared uncoated and SiO₂-coated NPs) and the organization of a muco-elastic extr

SUBMITTER: Camaioni A 

PROVIDER: S-EPMC8414698 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature