Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations.

ABSTRACT:

Background

Vascular malformations in the central nervous system are difficult to monitor and treat due to their inaccessible location. Angiogenic and inflammatory proteins are secreted into the bloodstream and may serve as useful biomarkers for identifying patients at risk for complications or with certain disease phenotypes.

Methods

A validated multiplex protein array consisting of 26 angiogenic and inflammatory biomarkers (Angiome) was assessed in plasma isolated from healthy controls and patients with either sporadic brain arteriovenous malformation (BAVM), familial cerebral cavernous malformation (CCM), or hereditary hemorrhagic telangiectasia (HHT). These samples were obtained from archives of ongoing research studies at the University of California San Francisco and th

SUBMITTER: Wetzel-Strong SE 

PROVIDER: S-EPMC8414780 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature