Prostaglandin E₂ Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases.

ABSTRACT: Prostaglandin E₂ (PGE₂) has been widely proposed to mediate neurovascular coupling by dilating brain parenchymal arterioles through activation of prostanoid EP4 receptors. However, our previous report that direct application of PGE₂ induces an EP1-mediated constriction strongly argues against its direct action on arterioles during neurovascular coupling, the mechanisms sustaining functional hyperemia. Recent advances have highlighted the role of capillaries in sensing neuronal activity and propagating vasodilatory signals to the upstream penetrating parenchymal arteriole. Here, we examined the effect of capillary stimulation with PGE₂ on upstream arteriolar diameter using an ex vivo capillary-parenchymal arteriole preparation and in viv

SUBMITTER: Rosehart AC 

PROVIDER: S-EPMC8414797 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature