DNA Methylation Age and Physical and Cognitive Aging.

ABSTRACT:

Background

DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be predictive of all-cause mortality but it is unclear what functional aspect(s) of aging it captures. We examine associations between four measures of AgeAccel in adults aged 45-87 years and physical and cognitive performance and their age-related decline.

Methods

AgeAccelHannum, AgeAccelHorvath, AgeAccelPheno, and AgeAccelGrim were calculated in the Medical Research Council National Survey of Health and Development (NSHD), National Child Development Study (NCDS) and TwinsUK. Three measures of physical (grip strength, chair rise speed, and forced expiratory volume in one second [FEV1]) and two measures of cognitive (episodic memory and mental speed) performance were assessed.

Results

AgeA

SUBMITTER: Maddock J 

PROVIDER: S-EPMC8414926 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature