Potential Clinical and Economic Value of Norovirus Vaccination in the Community Setting.

ABSTRACT:

Introduction

With norovirus vaccine candidates currently under development, now is the time to identify the vaccine characteristics and implementation thresholds at which vaccination becomes cost effective and cost saving in a community setting.

Methods

In 2020, a norovirus transmission, clinical, and economics computational simulation model representing different U.S. population segments was developed to simulate the spread of norovirus and the potential impact of vaccinating children aged <5 years and older adults (aged ≥65 years).

Results

Compared with no vaccination, vaccinating preschool-aged children averted 8%-72% of symptomatic norovirus cases in a community, whereas vaccinating older adults averted 2%-29% of symptomatic cases (varying with vaccine efficacy [2

SUBMITTER: Bartsch SM 

PROVIDER: S-EPMC8415104 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature