Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.

ABSTRACT: For decades, Parkinson's disease (PD) cases have been genetically categorised into familial, when caused by mutations in single genes with a clear inheritance pattern in affected families, or idiopathic, in the absence of an evident monogenic determinant. Recently, genome-wide association studies (GWAS) have revealed how common genetic variability can explain up to 36% of PD heritability and that PD manifestation is often determined by multiple variants at different genetic loci. Thus, one of the current challenges in PD research stands in modelling the complex genetic architecture of this condition and translating this into functional studies. Caenorhabditis elegans provide a profound advantage as a reductionist, economical model for PD research, with a short lifecycle, straightforward ge

SUBMITTER: Chandler RJ 

PROVIDER: S-EPMC8415217 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature