Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC.

ABSTRACT:

Background

Recurrence of liver metastasis after pancreatectomy is often a predictor of poor prognosis. Comprehensive genomic analysis may contribute to a better understanding of the molecular mechanisms of postoperative liver metastasis and provide new therapeutic targets.

Methods

A total of 67 patients from The Cancer Genome Atlas (TCGA) were included in this study. We analyzed differentially expressed genes (DEGs) by R package "DESeq2." Weighted gene co-expression network analysis (WGCNA) was applied to investigate the key modules and hub genes. Immunohistochemistry was used to analyze tumor cell proliferation index and CD4⁺ T cells infiltration.

Results

Functional analysis of DEGs between the liver metastatic and recurrence-free groups was mainly concent

SUBMITTER: Wang G 

PROVIDER: S-EPMC8415276 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature