Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer.

ABSTRACT:

Background

Dysregulation of glycogene expression in cancer can lead to aberrant glycan expression, which can promote tumorigenesis. Cervical cancer (CC) displays an increased expression of glycogenes involved in sialylation and sialylated glycans. Here, we show a comprehensive analysis of glycogene expression in CC to identify glycogene expression signatures and the possible glycosylation pathways altered.

Methods

First, we performed a microarray expression assay to compare glycogene expression changes between normal and cervical cancer tissues. Second, we used 401 glycogenes to analyze glycogene expression in adenocarcinoma and squamous carcinoma from RNA-seq data at the cBioPortal for Cancer Genomics.

Results

The analysis of the microarray expression assay indicated

SUBMITTER: Martinez-Morales P 

PROVIDER: S-EPMC8415283 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature