Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain.

ABSTRACT: Transposable elements (TEs) account for more than 50% of the human genome and many have been co-opted throughout evolution to provide regulatory functions for gene expression networks. Several lines of evidence suggest that these networks are fine-tuned by the largest family of TE controllers, the KRAB-containing zinc finger proteins (KZFPs). One tissue permissive for TE transcriptional activation (termed "transposcription") is the adult human brain, however comprehensive studies on the extent of this process and its potential contribution to human brain development are lacking. To elucidate the spatiotemporal transposcriptome of the developing human brain, we have analyzed two independent RNA-seq data sets encompassing 16 brain regions from eight weeks postconception into adulthood. We re

SUBMITTER: Playfoot CJ 

PROVIDER: S-EPMC8415367 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature