Delayed Disease in Cynomolgus Macaques Exposed to Ebola Virus by an Intranasal Route.

ABSTRACT: Ebola virus remains a significant public health concern due to high morbidity and mortality rates during recurrent outbreaks in endemic areas. Therefore, the development of countermeasures against Ebola virus remains a high priority, and requires the availability of appropriate animal models for efficacy evaluations. The most commonly used nonhuman primate models for efficacy evaluations against Ebola virus utilize the intramuscular or aerosol route of exposure. Although clinical disease signs are similar to human cases, disease progression in these models is much more rapid, and this can pose significant hurdles for countermeasure evaluations. The objective of the present study was to evaluate the Ebola virus disease course that arises after cynomolgus macaques are exposed to Ebola virus

SUBMITTER: Johnston SC 

PROVIDER: S-EPMC8415412 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature