Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin.

ABSTRACT: The phylogenetic analysis of proteins conventionally relies on the evaluation of amino acid sequences or coding sequences. Individual amino acids have measurable features that allow the translation from strings of letters (amino acids or bases) into strings of numbers (physico-chemical properties). When the letters are converted to measurable properties, such numerical strings can be evaluated quantitatively with various tools of complex systems research. We build on our prior phylogenetic analysis of the cytokine Osteopontin to validate the quantitative approach toward the study of protein evolution. Phylogenetic trees constructed from the number strings differentiate among all sequences. In pairwise comparisons, autocorrelation, average mutual information and box counting dimension yield

SUBMITTER: Wang X 

PROVIDER: S-EPMC8415472 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature