Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study.

ABSTRACT: Diffusion tensor imaging (DTI) is a noninvasive, quantitative MRI technique that measures white matter (WM) integrity. Many brain dimensions are heritable, including white matter integrity measured with DTI. Family studies are valuable to provide insights into the interactive effects of non-environmental factors on multiple sclerosis (MS). To examine the contribution of familial factors to the diffusion signals across WM microstructure, we performed DTI and calculated neurite orientation dispersion plus density imaging (NODDI) diffusion parameters in two patient groups comprising familial and sporadic forms of multiple sclerosis and their unaffected relatives. We divided 111 subjects (49 men and 62 women: age range 19-60) into three groups conforming to their MS history. The familial MS gr

SUBMITTER: Gharaylou Z 

PROVIDER: S-EPMC8415561 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature