COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases.

ABSTRACT: Epidemiological studies suggest that individuals with comorbid conditions including diabetes, chronic lung, inflammatory and vascular disease, are at higher risk of adverse COVID-19 outcomes. Genome-wide association studies have identified several loci associated with increased susceptibility and severity for COVID-19. However, it is not clear whether these associations are genetically determined or not. We used a Phenome-Wide Association (PheWAS) approach to investigate the role of genetically determined COVID-19 susceptibility on disease related outcomes. PheWAS analyses were performed in order to identify traits and diseases related to COVID-19 susceptibility and severity, evaluated through a predictive COVID-19 risk score. We utilised phenotypic data in up to 400,000 individuals from t

SUBMITTER: Papadopoulou A 

PROVIDER: S-EPMC8415605 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature