The effects of neoadjuvant chemotherapy and interval debulking surgery on body composition in patients with ovarian cancer.

ABSTRACT:

Background

The aim of this study was to quantify changes in body composition during ovarian cancer treatment and relate these changes to rates of complete gross resection (CGR).

Methods

One hundred two patients with stage III or IV ovarian cancer who underwent neoadjuvant chemotherapy (NACT) followed by interval debulking surgery were a part of a prospectively collected database that included computed tomography scans at three time points-diagnosis, following NACT, and following debulking surgery. Skeletal muscle, visceral adipose, and subcutaneous adipose tissue volumes were obtained from a 30-mm volumetric slab beginning at the third lumbar vertebrae.

Results

Following NACT, skeletal muscle volume was significantly reduced (352.5 to 335.0 cm³, P <

SUBMITTER: Vitarello J 

PROVIDER: S-EPMC8415724 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature