Distinct Immune Profiles of Exhausted Effector and Memory CD8⁺ T Cells in Individuals With Filarial Lymphedema.

ABSTRACT: CD8⁺ T cells are crucial for the clearance of viral infections, and current research begins to highlight their importance in parasitic diseases too. In-depth research about characteristics of CD8⁺ T-cell subsets and exhaustion remains uncertain, especially during filariasis, a chronic helminth infection. Lymphatic filariasis, elicited by Wuchereria bancrofti, remains a serious health problem in endemic areas in Ghana, especially in those suffering from morbidity due to lymphedema (LE). In this observational study, the characteristics and profiles of CD8⁺ T cells were compared between asymptomatic Wuchereria bancrofti-infected individuals, uninfected endemic normals, and those with LE (grades 2-6). Focusing on exhausted memory (CD8⁺e

SUBMITTER: Horn S 

PROVIDER: S-EPMC8415778 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature