Influence of Nutrition and Maternal Bonding on Postnatal Lung Development in the Newborn Pig.

ABSTRACT:

Background

Microbial colonization and immune cell maturation coincide at mucosal sites and are decisive for postnatal lung development. How external factors influence neonatal pulmonary immune development is poorly understood.

Objective

To elucidate the impact of key determinants in early life, nutrition, and maternal bonding, on postnatal lung maturation in a human-relevant animal model. To investigate the underlying immunological changes of impaired lung maturation and study the mechanisms of conversion.

Methods

Newborn piglets were kept with or without isolation from their mothers and fed bovine milk-based infant formula or received milk of sow. Lung growth, histomorphology, respiratory immune responses, and lung microbiota were analyzed. Mother- and sow-milk-depri

SUBMITTER: Schlosser-Brandenburg J 

PROVIDER: S-EPMC8415798 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature