CircCDYL Acts as a Tumor Suppressor in Wilms' Tumor by Targeting miR-145-5p.

ABSTRACT: Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. However, the possible mechanisms concerning the circRNA in various tumors are still elusive. In this research, we analyzed the expression profile and biological functions of circular RNA CDYL (circCDYL, circBase ID: hsa_circ_0008285) in Wilms' tumor. Here, miRNA and gene expression were examined by real-time PCR in Wilms' tumor tissues and cell lines. The functions of circCDYL and its potential targets to influence cell proliferation, migration, and invasion in Wilms' tumor cells were determined by biological functional experiments in vitro and in vivo. We predicted and analyzed potential miRNA targets through online bioinformatic tools. To validate the interactions between circCDY

SUBMITTER: Zhou R 

PROVIDER: S-EPMC8415843 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature