Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.

ABSTRACT: The habenula is a small bilateral epithalamic structure that plays a key role in the regulation of the main monoaminergic systems. It is implicated in many aspects of behavior such as reward processing, motivational behavior, behavioral adaptation, and sensory integration. A role of the habenula has been indicated in the pathophysiology of a number of neuropsychiatric disorders such as depression, addiction, obsessive-compulsive disorder, and bipolar disorder. Neuromodulation of the habenula using deep brain stimulation (DBS) as potential treatment has been proposed and a first successful case of habenula DBS was reported a decade ago. To provide an overview of the current state of habenula DBS in human subjects for the treatment of neuropsychiatric disorders we conducted a systematic revi

SUBMITTER: Germann J 

PROVIDER: S-EPMC8415908 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature