Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients.

ABSTRACT:

Purpose

This study aimed to determine the relationships among gut microbiota, primary aldosteronism (PA), and related metabolic disorders.

Methods

The study enrolled 13 PA patients, 26 sex-matched primary hypertension patients, and 26 sex-matched healthy controls. Demographic and clinical characteristics such as age, body mass index (BMI), blood aldosterone-renin ratio, blood potassium, blood glucose, blood lipid parameters, and history of diabetes mellitus (DM) were compared between the three groups. The gut microbiota of each participant was examined by 16S rRNA gene sequencing. Spearman correlation analysis was performed to demonstrate the relationship between gut microbiota and clinical characteristics.

Results

BMI and the percentage of DM in PA patients were high

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8415980 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature