Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen Alternaria alternata.

ABSTRACT: Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated with severe airway inflammation, while their precise contribution to the severe inflammation is largely unknown. We aimed to study the role of neutrophils in BALB/c and C57BL/6 mice exposed to Alternaria alternata (Alt). The mice were exposed to Alt extract for twelve hours or ten days to induce allergic airway inflammation. C57BL/6 mice exposed to Alt responded with eosinophilic infiltration and the characteristic IL-5 upregulation. In contrast, the inflammatory response to Alt extract in BALB/c mice was charac

SUBMITTER: Van Nevel S 

PROVIDER: S-EPMC8416032 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature