Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease.

ABSTRACT: Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It affects nearly 95% of all protein-coding genes and occurs in nearly all human organs. Aberrant alternative splicing can lead to various neurological diseases and cancers and is responsible for aging, infection, inflammation, immune and metabolic disorders, and so on. Though aberrant alternative splicing events and their regulatory mechanisms are widely recognized, the association between autoimmune disease and alternative splicing has not been extensively examined. Autoimmune diseases are characterized by the loss of tolerance of the immune system towards self-antigens and organ-specific or systemic inflammation and subsequent tissue damage. In the present review, we summarized the most recent repor

SUBMITTER: Ren P 

PROVIDER: S-EPMC8416054 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature