Characterizing Early T Cell Responses in Nonhuman Primate Model of Tuberculosis.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading infectious disease killer worldwide with 1.4 million TB deaths in 2019. While the majority of infected population maintain an active control of the bacteria, a subset develops active disease leading to mortality. Effective T cell responses are critical to TB immunity with CD4⁺ and CD8⁺ T cells being key players of defense. These early cellular responses to TB infection have not yet been studied in-depth in either humans or preclinical animal models. Characterizing early T cell responses in a physiologically relevant preclinical model can provide valuable understanding of the factors that control disease development. We studied Mtb-specific T cell responses in the lung compar

SUBMITTER: Sharan R 

PROVIDER: S-EPMC8416058 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature