Graves' Disease and Rheumatoid Arthritis: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

The frequent coexistence of Graves' disease (GD) and rheumatoid arthritis (RA) has been cited and discussed in observational studies, but it remains a question as to whether there is a causal effect between the two diseases.

Methods

We retrieved genome-wide association study (GWAS) summary data of GD and RA from BioBank Japan (BBJ). Single nucleotide polymorphisms (SNPs) associated with diseases of interest were selected as instrumental variables (IVs) at a genome-wide significance level (P < 5.0 × 10^-8). The random-effects inverse variance weighted method (IVW) was used to combine the causal effect of IVs. The horizontal pleiotropy effect was analyzed by MR-Egger and weighted median method sensitivity test. A leave-one-out analysis was conducted

SUBMITTER: Wu D 

PROVIDER: S-EPMC8416061 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature