Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC8416095 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Li Hong H Jiang Xueqin X Shen Xin X Sun Yueshan Y Jiang Nan N Zeng Jing J Lin Jing J Yue Liang L Lai Jia J Li Yan Y Wu Anguo A Wang Long L Qin Dalian D Huang Feihong F Mei Qibing Q Yang Jing J Wu Jianming J
Frontiers in cell and developmental biology 20210817
Thrombocytopenia is closely linked with hemorrhagic diseases, for which induction of thrombopoiesis shows promise as an effective treatment. Polyphenols widely exist in plants and manifest antioxidation and antitumour activities. In this study, we investigated the thrombopoietic effect and mechanism of 3,3',4'-trimethylellagic acid (TMEA, a polyphenol in <i>Sanguisorba officinalis</i> L.) using <i>in silico</i> prediction and experimental validation. A KEGG analysis indicated that PI3K/Akt signa ...[more]