The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review.

ABSTRACT: Background: The triad of drug efficacy, toxicity and resistance underpins the risk-benefit balance of all therapeutics. The application of pharmacogenomics has the potential to improve the risk-benefit balance of a given therapeutic via the stratification of patient populations based on DNA variants. A growth in the understanding of the particulars of the mitochondrial genome, alongside the availability of techniques for its interrogation has resulted in a growing body of literature examining the impact of mitochondrial DNA (mtDNA) variation upon drug response. Objective: To critically evaluate and summarize the available literature, across a defined period, in a systematic fashion in order to map out the current landscape of the subject area and identify how the field may co

SUBMITTER: Jones SW 

PROVIDER: S-EPMC8416105 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature