Open Culture Ethanol-Based Chain Elongation to Form Medium Chain Branched Carboxylates and Alcohols.

ABSTRACT: Chain elongation fermentation allows for the synthesis of biobased chemicals from complex organic residue streams. To expand the product spectrum of chain elongation technology and its application range we investigated 1) how to increase selectivity towards branched chain elongation and 2) whether alternative branched carboxylates such as branched valerates can be used as electron acceptors. Elongation of isobutyrate elongation towards 4-methyl-pentanoate was achieved with a selectivity of 27% (of total products, based on carbon atoms) in a continuous system that operated under CO₂ and acetate limited conditions. Increasing the CO₂ load led to more in situ acetate formation that increased overall chain elongation rate but decreased the selectivity of branched c

SUBMITTER: de Leeuw KD 

PROVIDER: S-EPMC8416115 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature