Dataset Information

Modulation of Peripheral CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice.

ABSTRACT: Systemic inflammation associated with major surgery rapidly accelerates atherosclerotic plaque progression in mice. Regulatory T cells (Tregs) have emerged as important modulators of atherogenesis. In coronary artery disease patients, low frequency of Tregs constitutes an independent risk factor for cardiovascular complications after non-cardiac surgery. In this exploratory analysis, we investigate whether preoperative Treg levels affect surgery-induced atherosclerotic lesion destabilization in a murine model of perioperative stress. After 9 weeks of high-cholesterol diet, atherosclerotic apolipoprotein E-deficient mice with modulated Treg levels were subjected to a 30-minute surgical procedure consisting of general isoflurane anesthesia, laparotomy and moderate blood loss. Controls underw

SUBMITTER: Handke J

PROVIDER: S-EPMC8416168 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Modulation of Peripheral CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Modulation of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Modulation of Peripheral CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice.