Molecular Mechanism of Jinchan Oral Liquid in the Treatment of Children with Respiratory Syncytial Virus Pneumonia Based on Network Pharmacology and Molecular Docking Technology.

ABSTRACT:

Objective

Exploration of the underlying molecular mechanism of Jinchan Oral Liquid (JOL) in treating children with the respiratory syncytial virus (RSV) pneumonia to provide new evidence for the clinical application.

Methods

The active components and target genes of JOL were screened by the TCMSP database. The targets of RSV pneumonia were obtained from the GeneCards, OMIM, DrugBank, and PharmGKB database. Then, we constructed the active component-target network and screened the core genes. The overlaps were screened for PPI network analysis, GO analysis, and KEGG analysis. Finally, result validation was performed by molecular docking.

Results

According to the screening criteria of the ADME, 74 active compounds of JOL were obtained; after removing redundant targets, w

SUBMITTER: Shen L 

PROVIDER: S-EPMC8416387 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature