Gene Signatures and Prognostic Values of N6-Methyladenosine Related Genes in Ovarian Cancer.

ABSTRACT: N6-Methyladenosine (m⁶A) is one of the most prominent modification regulating RNA processing and metabolism. Increasing studies have illuminated the vital role of m⁶A methylation in carcinogenesis. However, little is known about the interaction between m⁶A-related genes and survival of ovarian cancer (OC) patients. The purpose of this study was to obtain more reliable m⁶A-related genes that could be used as prognostic markers of OC using bioinformatics analysis performed on the RNA-seq data of OC. Gene expression datasets of all m⁶A-related genes as well as corresponding clinical data were obtained from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) databases. We detected differential expressed m

SUBMITTER: Na Z 

PROVIDER: S-EPMC8416414 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature