Fuzzle 2.0: Ligand Binding in Natural Protein Building Blocks.

ABSTRACT: Modern proteins have been shown to share evolutionary relationships via subdomain-sized fragments. The assembly of such fragments through duplication and recombination events led to the complex structures and functions we observe today. We previously implemented a pipeline that identified more than 1,000 of these fragments that are shared by different protein folds and developed a web interface to analyze and search for them. This resource named Fuzzle helps structural and evolutionary biologists to identify and analyze conserved parts of a protein but it also provides protein engineers with building blocks for example to design proteins by fragment combination. Here, we describe a new version of this web resource that was extended to include ligand information. This addition is a s

SUBMITTER: Ferruz N 

PROVIDER: S-EPMC8416435 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature