Alterations in Urine Metabolomics Following Sport-Related Concussion: A ¹H NMR-Based Analysis.

ABSTRACT: Objective: Millions of sport-related concussions (SRC) occur annually in North America, and current diagnosis of concussion is based largely on clinical evaluations. The objective of this study was to determine whether urinary metabolites are significantly altered post-SRC compared to pre-injury. Setting: Outpatient sports medicine clinic. Participants: Twenty-six male youth sport participants. Methods: Urine was analyzed pre-injury and after SRC by ¹H NMR spectroscopy. Data were analyzed using multivariate statistics, pairwise t-test, and metabolic pathway analysis. Variable importance analysis based on random variable combination (VIAVC) was applied to the entire data set and resulted in a panel of 18 features. Partial least square discrimina

SUBMITTER: Wanner ZR 

PROVIDER: S-EPMC8416667 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature